A rapid discovery platform
Kinase Privileged Scaffolds (KIPS) are identified by screening classes of compounds with specific activity and selectivity
Multicomponent chemical synthesis reactions are used as a rapid chemistry platform the generate libraries of compounds
Tailored drug design with molecular precision
Once lead compounds are identified we apply our proprietary medicinal chemistry pipeline to generate compounds with optimal drug-like properties.
This will increase the chances of bio-availability and reduce the risk of unwanted side effects.
Rational selectivity
Screen compounds which can potently inhibit both the primary target and drug resistant mutations that arise during treatment.
Focus on compounds that also target collaborating kinases that contribute to disease progression.
A proprietary kinase inhibitor library
Using our scientific expertise and proprietary technology we have generated a library of compounds that includes many best-in-class drug candidates.
Our discovery engine constantly expands and refines this library.
Publications
Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines
Identification of New FLT3 Inhibitors That Potently Inhibit AML Cell Lines via an Azo Click-It/Staple-It Approach
Alkynylnicotinamide-based compounds as ABL1 inhibitors with potent activities against drug-resistant CML harboring ABL1(T315I) mutant kinase.
Elizabeth A. Larocquea, Dr. N Nagannaa, Clement Opoku-Temenga,b, Alyssa M. Lambrechta, and Prof. Dr. Herman O. Sintima